CDr17 is selective for M1 macrophages over M2 and M0 macrophages. The selective staining mechanism of CDr17 is explained as Gating-Oriented Live-cell Distinction (GOLD) through overexpressed GLUT1 in M1 macrophages. Additionally, CDr17 has been demonstrated to effectively track M1 macrophages in vivo in a rheumatoid arthritis animal model.
■ Cell Image
Selectivity of CDr17 to M1 over M0 or M2 macrophages from RAW264.7 and relative fluorescent intensity (FI) of CDr17.
Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target. Cho H, Kwon HY, Sharma A, Lee SH, Liu X, Miyamoto N, Kim JJ, Im SH, Kang NY, Chang YT. Angew. Chem. Int. Ed. Engl. 2019, 58, 7972-7976.
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■ General Use Guide
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More than 1/100 dilution of 10mM of DMSO stock solution is essential
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For biomedical use to avoid DMSO concentration higher than 1%.
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Working concentrations for specific applications should be determined by the investigator.
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It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or precipitated out from buffer solution.
