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HCC probes

hLR (healthy Liver Red) [Catalog #P059]

■ Chemical structure & Information
cLG was selective for liver cancer cells, whereas hLR was selective for healthy liver cells. These two probes selectively stained the targeted cells in the liver section, which was confirmed by H&E and antibody staining. In addition, the use of a cocktail of these two probes provided high contrast between the cancerous region and the normal region, enabling accurate cancer imaging.
■ Image
Healthy liver cell recognition in the cancerousliver section using hLR. (a) The liver tissues were incubated with hLR (10 μM) for 30 min. (b) H&E staining of the liver tissues. (c) Colocalization of anti-GPC and hLR in the liver tissue. Concordant results were obtained from three independent experiments.
Costaining of cLG and hLR in cancerous liver tissue. The cocktail was made with hLR (10 μM) and cLG (5 μM). The tissue section was incubated with cocktail for 30 min. Tissue thickness is 15 μm. Concordant results were obtained from three independent experiments.
■ Related probes: cLG
■ Known Property
Liver healthy cell selective probe
■ Application
fluorescence image
■ Cell selectivity mechanism
POLD (SMPD1)
■ Reference
1.
A Pair of Fluorescent Probes Enabling Precise Diagnosis of Liver Cancer by Complementary Imaging, Gao M, Lee SH, Kwon HY, Ciaramicoli LM, Jo E, Yu YH, Li F, Kim B, Hong K, Lee JS, Kim N, Oh Y, Im CY, Tan CSH, Ha HH, Chang YT., ACS Cent Sci., 2024 Dec 16;11(1):76-83.

■ ORDER
International
USD 350 + VAT (10%) + Fedex delivery charge
In Korea
KRW 450,000 + VAT (10%)
100 nmol (dried form: equvalent to 1 mM / 100 µL)

■ Storage
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

■ General Use Guide
•
More than 1/100 dilution of 10mM of DMSO stock solution is essential
•
For biomedical use to avoid DMSO concentration higher than 1%.
•
Working concentrations for specific applications should be determined by the investigator.
•
It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
precipitated out from buffer solution.
■ Data sheet PDF file/
hLR data sheet.pdf456.74KB
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